2015•The Journal of Infectious DiseasesRequires access

Comparison of Immunogenicity Between Inactivated and Live Attenuated Hepatitis A Vaccines Among Young Adults: A 3-Year Follow-up Study

Xueen Liu, Haiying Chen, Zheng Liao, Yisheng Zhou, Hairong Wen, Shihui Peng, Yan Liu, Rui Li, Jie Li, Hui Zhuang

Abstract

UNLABELLED: A randomized clinical trial of hepatitis A vaccines (1 or 2 doses of inactivated vaccine [Healive] or 1 dose of live attenuated vaccine [Biovac]) was conducted among adults to evaluate seroprotection rates and geometric mean concentrations of antibody against hepatitis A virus for 36 months. High rates of seroprotection persisted for at least 36 months among adults who received 1 or 2 doses of inactivated hepatitis A vaccine but not among adults who received 1 dose of live attenuated hepatitis A vaccine. The long-term serial monitoring of immunogenicity induced by 1 dose of inactivated hepatitis A vaccine is needed to determine an effective alternative to a 2-dose schedule. CLINICAL TRIALS REGISTRATION: NCT01865968.

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Key concepts: Immunogenicity, Hepatitis A vaccine, Medicine, Attenuated vaccine, Inactivated vaccine, Hepatitis A, Virology, Immunology