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2014•Journal of Travel MedicineRequires access

Failure of Repeated Treatment With Praziquantel and Arthemeter in Four Patients With Acute Schistosomiasis

Liliana Praticò, B Mariani, Enrico Brunetti, R. Maserati, Antonella Bruno, Stefano Novati, Guido Chichino

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Abstract

Schistosomiasis is on the rise but still difficult to treat in international travelers; it should be suspected in patients returning from endemic areas. Praziquantel (PZQ) is not effective and may aggravate symptoms. More recently, combination treatment with artemisinin derivatives have shown promising results. We report four cases of acute schistosomiasis (AS) in which several courses of combined therapy had been necessary to obtain negative serology.

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What this paper is about

Schistosomiasis is on the rise but still difficult to treat in international travelers; it should be suspected in patients returning from endemic areas. Praziquantel (PZQ) is not effective and may aggravate symptoms. More recently, combination treatment with artemisinin derivatives have shown promising results. We report four cases of acute schistosomiasis (AS) in which several courses of combined therapy had been necessary to obtain negative serology.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Schistosomiasis is on the rise but still difficult to treat in international travelers; it should be suspected in patients returning from endemic areas. Praziquantel (PZQ) is not effective and may aggravate symptoms. More recently, combination treatment with artemisinin derivatives have shown promising results. We report four cases of acute schistosomiasis (AS) in which several courses of combined therapy had been necessary to obtain negative serology.

Key concepts: Praziquantel, Medicine, Schistosomiasis, Artemisinin, Serology, Helminthiasis, Internal medicine, Immunology

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Failure of Repeated Treatment With Praziquantel and Arthemeter in Four Patients With Acute Schistosomiasis — Research Paper | ScholarLens