1977•JNCI Journal of the National Cancer InstituteRequires access

Inhibition of Tumor Growth by the Peptidoglycan From Bacillus megaterium 2

C Nauciel, A Goguel

Abstract

When injected in admixture with tumor cells, the peptidoglycan extracted from Bacillus megaterium inhibited the growth of a chemically induced fibrosarcoma in syngeneic rats. In some instances, the tumor growth was totally suppressed. Animals rejecting mixed inocula exhibited a tumor-specific immunity. Peptidoglycan was not cytotoxic for tumor cells; it rendered macrophages nonspecifically cytotoxic.

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Key concepts: Bacillus megaterium, Peptidoglycan, Cytotoxic T cell, Fibrosarcoma, Immunity, Microbiology, Cytotoxicity, Chemistry