2000•The Journal of Clinical PharmacologyRequires access

Effect of Chlorpromazine and Clozapine on Plasma Concentrations of Haloperidol in a Patient with Schizophrenia

Sharon A. Allen

Abstract

A 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (HAL) in combination with chlorpromazine (CPZ) and during overlap treatment with clozapine. Competitive inhibition of HAL by first CPZ and then clozapine is discussed as a possible mechanism.

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Key concepts: Clozapine, Haloperidol, Chlorpromazine, Schizophrenia (object-oriented programming), Pharmacology, Plasma concentration, Plasma levels, Medicine