1987•Journal of BacteriologyOpen access

Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant

Yasushi Inoue, Kenichi Sato, Tatsuya Fujii, Keiji Hirai, Manabu Inoue, Shizuko Iyobe, S Mitsuhashi

Abstract

Subunits A and B of DNA gyrase were purified from Pseudomonas aeruginosa PAO1 and its mutant, which was resistant to nalidixic acid. Inhibition tests of DNA gyrases reconstituted with a combination of subunits from the two strains showed that an alteration of subunit A but not subunit B caused bacteria to resist fluoroquinolones.

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Key concepts: Nalidixic acid, DNA gyrase, Biology, Mutant, Pseudomonas aeruginosa, Protein subunit, DNA, Microbiology