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ANTI-DIABETIC ACTIVITY OF TERMINALIA CATAPPA LINN. LEAF EXTRACTS IN ALLOXAN-INDUCED DIABETIC RATS

Syed Mansoor Ahmed, B.M. Vrushabendra Swamy, P Gopkumar, Ramaiyan Dhanapal, V. M. Chandrashekara

Abstract

In view of suggested anti diabetic potential, effect of aqueous and cold extracts of Terminalia Catappa Linn (Combretaceae) leaves, on fasting blood sugar levels and serum biochemical analysis in alloxaninduced diabetic rats was investigated. All the extracts of Terminalia Catappa produced a significant anti diabetic activity at dose levels of 1/5th of their lethal doses. Concurrent histological studies of the pancreas of these animals showed regeneration by aqueous and cold extracts which were earlier necrosed by alloxan.

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Key concepts: Alloxan, Terminalia, Combretaceae, Blood sugar, Traditional medicine, Aqueous extract, Diabetes mellitus, Chemistry