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Avidity of anti-β2-glycoprotein I antibodies in patients with antiphospholipid syndrome

Saša Čučnik, Tanja Kveder, Andrej Artenjak, Z Ulcova Gallova, Jakub Swadźba, Jacek Musiał, Teresa Iwaniec, Ljudmila Stojanovich, Cristiano Alessandri, Guido Valesini, Tadej Avčin, JW Cohen Tervaert, Blaž Rozman, Borut Božič

Open publisher page 25 citations

Abstract

Antibodies against β(2)-glycoprotein I (anti-β(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-β(2)GPI antibodies. Our results confirmed that high avidity anti-β(2)GPI are associated with thrombosis and APS, while in low avidity anti-β(2)GPI group non-APS (predominantly systemic lupus erythematosus) patients prevailed.

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What this paper is about

Antibodies against β(2)-glycoprotein I (anti-β(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-β(2)GPI antibodies. Our results confirmed that high avidity anti-β(2)GPI are associated with thrombosis and APS, while in low avidity anti-β(2)GPI group non-APS (predominantly systemic lupus erythematosus) patients prevailed.

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OpenAlex reports 25 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Antibodies against β(2)-glycoprotein I (anti-β(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-β(2)GPI antibodies. Our results confirmed that high avidity anti-β(2)GPI are associated with thrombosis and APS, while in low avidity anti-β(2)GPI group non-APS (predominantly systemic lupus erythematosus) patients prevailed.

Key concepts: Avidity, Antiphospholipid syndrome, Medicine, Antibody, Immunology, Epitope, Glycoprotein, Biology

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