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GENE CONVERSION: A HITHERTO OVERLOOKED PARAMETER IN POPULATION GENETICS

Herbert Gütz, John F. Leslie

Abstract

Gene conversion causes deviations from the 2:2 segregation of allele pairs in meiosis. Thus, gene conversion is a potential cause for changes of allele frequencies in populations. Equations are derived for the effects of conversion in a large random-mating population. The influence of gene conversion on allele frequencies is compared with that of spontaneous mutation and meiotic drive.

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Key concepts: Gene conversion, Genetics, Biology, Allele, Meiosis, Gene, Allele frequency, Meiotic drive