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1974•The Journal of ImmunologyRequires access

Antisera to Human Cytomegaloviruses Prepared in the Guinea Pig: Specific Immunofluorescence and Complement Fixation Tests

Yung-Tsun Huang, Eng‐Shang Huang, Joseph S. Pagano

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Abstract

Abstract Specific, high titered antisera to human (C-87 and AD-169) and simian (GR-2757) cytomegaloviruses were prepared in guinea pigs and used in complement fixation (CF) and immunofluorescence (IF) tests. There were no detectable cellular antibodies in the antisera. Both the CF and the IF tests revealed that the two human strains are closely related or identical and have little if any interspecies cross-reactivity with the simian strain.

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What this paper is about

Abstract Specific, high titered antisera to human (C-87 and AD-169) and simian (GR-2757) cytomegaloviruses were prepared in guinea pigs and used in complement fixation (CF) and immunofluorescence (IF) tests. There were no detectable cellular antibodies in the antisera. Both the CF and the IF tests revealed that the two human strains are closely related or identical and have little if any interspecies cross-reactivity with the simian strain.

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Available abstract

Abstract Specific, high titered antisera to human (C-87 and AD-169) and simian (GR-2757) cytomegaloviruses were prepared in guinea pigs and used in complement fixation (CF) and immunofluorescence (IF) tests. There were no detectable cellular antibodies in the antisera. Both the CF and the IF tests revealed that the two human strains are closely related or identical and have little if any interspecies cross-reactivity with the simian strain.

Key concepts: Antiserum, Complement fixation test, Immunofluorescence, Guinea pig, Biology, Simian, Indirect immunofluorescence, Virology

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