Cromolyn and Nedocromil

Both nedocromil sodium and cromolyn sodium are anti-inflammatory drugs that may be used in the therapy of allergic diseases. These diseases include asthma, allergic rhinitis, and allergic ocular disorders. Additional therapeutic uses have been proposed. Nedocromil and cromolyn are both available in the United States for asthma therapy, but only cromolyn is available for the treatment of the other conditions. Recent publications in the evidence-based literature have upheld the safety profile of nedocromil and cromolyn but increasingly suggest that other topical anti-inflammatory agents are more effective and have comparable safety at recommended doses. Nedocromil sodium and cromolyn sodium both can be used prophylactically prior to isolated allergen exposures and must be used regularly for maintenance therapy. No consistent, severe adverse reactions occur with either drug.