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2013•The African Journal of Pharmacology and TherapeuticsRequires access

The effect of Lisinopril on blood glucose level given alone and in combination with oral anti-diabetic drugs in alloxan-induced diabetic rats

Neeraj Agrawal, Uma Gupta

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Abstract

Background: In diabetic patients, ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with oral anti-diabetic drugs in these conditions. The picture of actual impact of ACE inhibitors on blood glucose is controversial and still not clear. This study therefore aimed to evaluate the effect of Lisinopril on blood glucose level and the interaction with the oral anti-diabetic drugs metformin, gliclazide and pioglitazone in alloxan induced diabetic rats.

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What this paper is about

Background: In diabetic patients, ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with oral anti-diabetic drugs in these conditions. The picture of actual impact of ACE inhibitors on blood glucose is controversial and still not clear. This study therefore aimed to evaluate the effect of Lisinopril on blood glucose level and the interaction with the oral anti-diabetic drugs metformin, gliclazide and pioglitazone in alloxan induced diabetic rats.

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Available abstract

Background: In diabetic patients, ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with oral anti-diabetic drugs in these conditions. The picture of actual impact of ACE inhibitors on blood glucose is controversial and still not clear. This study therefore aimed to evaluate the effect of Lisinopril on blood glucose level and the interaction with the oral anti-diabetic drugs metformin, gliclazide and pioglitazone in alloxan induced diabetic rats.

Key concepts: Lisinopril, Medicine, Alloxan, Gliclazide, Metformin, Diabetes mellitus, Diabetic nephropathy, Pharmacology

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The effect of Lisinopril on blood glucose level given alone and in combination with oral anti-diabetic drugs in alloxan-induced diabetic rats — Research Paper | ScholarLens