2003•Journal of Periodontal ResearchRequires access
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent
Luís Carlos Spolidório, Denise Madalena Palomari Spolidório, C Benatti, José Eduardo Cézar Sampaio, Oslei Paes de Almeida
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Abstract
BACKGROUND: Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity. OBJECTIVE: The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently. MATERIALS AND METHODS: Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow. RESULTS: Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine. CONCLUSION: These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.