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Inflammation and inflammatory bowel disease

Christopher G. Mathew

Open publisher page 3 citations

Abstract

Abstract The identification ofNOD2(now calledCARD15) as a susceptibility gene for Crohn's disease was a major milestone in the genetics of inflammatory bowel disease, and appears to provide an important link between pathogen recognition and activation of the inflammatory response. Regions of extensive linkage disequilibrium and modest genetic effects are likely to pose significant challenges in the search for novel susceptibility genes.

About this research paper

What this paper is about

Abstract The identification ofNOD2(now calledCARD15) as a susceptibility gene for Crohn's disease was a major milestone in the genetics of inflammatory bowel disease, and appears to provide an important link between pathogen recognition and activation of the inflammatory response. Regions of extensive linkage disequilibrium and modest genetic effects are likely to pose significant challenges in the search for novel susceptibility genes.

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Method / approach

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Available abstract

Abstract The identification ofNOD2(now calledCARD15) as a susceptibility gene for Crohn's disease was a major milestone in the genetics of inflammatory bowel disease, and appears to provide an important link between pathogen recognition and activation of the inflammatory response. Regions of extensive linkage disequilibrium and modest genetic effects are likely to pose significant challenges in the search for novel susceptibility genes.

Key concepts: NOD2, Inflammatory bowel disease, Linkage disequilibrium, Disease, Identification (biology), Inflammation, Milestone, Genetics

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