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2015•ChemMedChemRequires access

The Role of Target Binding Kinetics in Drug Discovery

Dong Ming Guo, Laura H. Heitman, Adriaan P. IJzerman

Open publisher page 53 citations

Abstract

Traditionally structure-activity/affinity relationships (SAR) have dominated research in medicinal chemistry. However, structure-kinetics relationships (SKR) can be very informative too. In this viewpoint we explore the molecular determinants of binding kinetics and discuss challenges for future binding kinetics studies. A scheme for future kinetics-directed drug design and discovery is also proposed.

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What this paper is about

Traditionally structure-activity/affinity relationships (SAR) have dominated research in medicinal chemistry. However, structure-kinetics relationships (SKR) can be very informative too. In this viewpoint we explore the molecular determinants of binding kinetics and discuss challenges for future binding kinetics studies. A scheme for future kinetics-directed drug design and discovery is also proposed.

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OpenAlex reports 53 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Traditionally structure-activity/affinity relationships (SAR) have dominated research in medicinal chemistry. However, structure-kinetics relationships (SKR) can be very informative too. In this viewpoint we explore the molecular determinants of binding kinetics and discuss challenges for future binding kinetics studies. A scheme for future kinetics-directed drug design and discovery is also proposed.

Key concepts: Kinetics, Receptor–ligand kinetics, Drug discovery, Computational biology, Chemistry, Enzyme kinetics, Drug, Biophysics

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