Practical Management of CD30+ Lymphoproliferative Disorders

Lymphomatoid papulosis Primary cutaneous anaplastic large cell cutaneous lymphoma Mycosis fungoides with large cell transformation CD30 1 cutaneous lymphoproliferative disorders KEY POINTSThe CD30 1 cutaneous lymphoproliferative disorders can look similar both clinically and histologically.Evaluation by a clinician and dermatopathologist with expertise in cutaneous lymphomas is invaluable in the correct classification of these disorders.Correct classification sets the stage for choosing an appropriate treatment regimen for each of these disorders.Lymphomatoid papulosis (LyP) rarely requires systemic therapy, whereas refractory or multifocal cutaneous anaplastic large cell lymphoma (cALCL) and mycosis fungoides (MF) with large cell transformation (LCT) may require systemic therapy in combination with skindirected therapy.Given the chronic nature and typical good prognosis of most CD30 1 lymphoproliferative disorders (LPDs), the clinician should take into account possible deleterious long-term side effects of treatment options.