1988•Molecular and Cellular BiologyOpen access

Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.

Karin Rodland, Leslie L. Muldoon, T H Dinh, Bruce E. Magun

Abstract

A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation. Following TPA-induced depletion of protein kinase C activity, EGF stimulation of VL30 transcription and accumulation was unaffected while TPA effects were inhibited, implying that EGF and TPA act by separable pathways.

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Key concepts: Protein kinase C, Biology, 12-O-Tetradecanoylphorbol-13-acetate, Epidermal growth factor, Tetradecanoylphorbol Acetate, Cell biology, Transcription factor, Molecular biology