The dependence of the activity of alanine aminotransferase on the gender of the patient in viral hepatitis B

Aim. To reveal the dependence of alanine aminotransferase on the gender of the patient in the inactive form of chronic viral hepatitis B. Methods. Instrumental determination of the activity of alanine aminotransferase in 64 healthy subjects (32 males and 32 females) and 255 patients with an inactive form of chronic viral hepatitis B. According to the time of infection the patients were divided into three groups: up to 5 years, 5-10 years, and more than 10 years. Results. Normal alanine aminotransferase activity was detected in 18 (21.4%) males and 66 (78.6%) females. Among the 34 patients with constantly high indices of alanine aminotransferase activity were 24 (70.6%) males and 10 (29.4%) females, that is, increased activity is 2.8 times more frequently recorded in males. The higher absolute index of this enzyme’s activity (IU/L) in males was noted with disease duration of 5-10 years (1.25 times average increase in activity) and 10 years or more (1.5 times). Conclusion. The more marked and frequent increase in alanine aminotransferase activity among males with chronic viral hepatitis B, should be considered when interpreting the results of laboratory tests.