2009•Chinese Veterinary ScienceRequires access

Effects of main virulent genes of pseudorabies virus on their cytopathogenicity.

Ling Zhu, Guo Wan-zhu, Yin Wang, Aiguo Yang, Tian Shi, Kai Xu, Ling Zhao

Abstract

The TK-deleted strain,the gI-gE-deleted strain and the TK-gI-gE-deleted strain of pseudo-rabies virus(PRV) and a PRV Fa strain were used to infect IBRS-2,Marc-145,ST,Vero and MDBK cells at dosage of 0.5mL(1×106PFU/mL).The cellular morphometric changes were observed at hours 0,8,12,24,36 and 48 post-infection,respectively.All the four strains of virus could proliferate and induce cytopathic effect(CPE) on the five cell lines,but there was diversity in the emergence time and characteristics of CPE among them.The CPE resulted from PRV Fa strain was more serious than those from the other 3 strains.The results indicated that different virulence genes of PRV possessed different ability of CPE.

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Key concepts: Virulence, Vero cell, Biology, Pseudorabies, Strain (injury), Cytopathic effect, Virology, Virus