1975•PubMedOpen access

Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media.

Gillian Cameron, A. C. Pomahac, Melinda Johnston

Abstract

Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection. They received either of these two agents according to a double-blind randomized procedure that also took the child's weight into account. No significant difference was found in the clinical outcome between the two treatment regimens. Undesirable side effects from TMP-SMX were notably few.

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Key concepts: Trimethoprim, Ampicillin, Sulfamethoxazole, Medicine, Otitis, Acute otitis media, Randomized controlled trial, Internal medicine