2006Encyclopedia of Life SciencesRequires access

Telomeres and Telomerase in Aging and Cancer

Michel M. Ouellette

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Abstract

Abstract Telomeres protect the ends of chromosomes and shorten each time somatic human cells divide. As a consequence, cells enter senescence after a limited number of divisions. The enzyme telomerase expressed in rare cells of the skin, blood and intestine can prevent the shortening of telomeres and extend cellular lifespan.

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What this paper is about

Abstract Telomeres protect the ends of chromosomes and shorten each time somatic human cells divide. As a consequence, cells enter senescence after a limited number of divisions. The enzyme telomerase expressed in rare cells of the skin, blood and intestine can prevent the shortening of telomeres and extend cellular lifespan.

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Available abstract

Abstract Telomeres protect the ends of chromosomes and shorten each time somatic human cells divide. As a consequence, cells enter senescence after a limited number of divisions. The enzyme telomerase expressed in rare cells of the skin, blood and intestine can prevent the shortening of telomeres and extend cellular lifespan.

Key concepts: Telomere, Telomerase, Somatic cell, Senescence, Biology, Cellular senescence, Cellular Aging, Cancer

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