1993•Annals of the New York Academy of SciencesRequires access
From Proopiomelanocortin to Cancer
Majambu Mbikay, Nabil G. Seidah, Michel Chrétien
Open publisher page 17 citations
Abstract
Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for proliferative diseases like cancer.