1993•PubMedOpen access
Capillarization of the hepatic sinusoid in failed liver grafts.
K Noguchi, A Yagihashi, Masanobu Kobayashi, Yuki Yoshida, Ken‐ichiro Tanaka, A Konno, Shusaku Hayashi, Kenjiro Terasawa, K Nakamura, A.J. Demetris
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Abstract
In the normal hepatic acinus, the basement membrane is not seen in the hepatic perisinusoidal space, called Disse’s space. 1 However, it has been reported that the hepatic sinusoidal wall has the basement membrane formation and resembles the capillary in chronic liver disease such as cirrhosis of the liver. 2,3 This alteration has been suggested to advance damage of the parenchymal cells due to the disturbed exchange of metabolites between blood and parenchymal cell. 3,4 The aim of this study was to estimate the role of the hepatic sinusoidal capillarization in failed liver grafts from various causes after transplantation.