1958•Proceedings of the Japan AcademyOpen access

The Enzymatic Hydroxylation of Benzoic and Phenylacetic Acids. A New Pathway to Homogentisic Acid

KANJI INAMORI, HANZO NASU, Yukiya Sakamoto, KATASHI ICHIHARA

Abstract

The rabbit liver enzyme, when TPN and citrate were added, converted benzoic acid to m-hydroxybenzoic acid, p-hydroxybenzoic acid to protocatechuic acid, m-hydroxybenzoic acid to protocatechuic acid and gentisic acid, salicylic acid to gentisic acid, phenylacetic acid to p- and o-hydroxyphenylacetic acids, p-hydroxyphenylacetic acid to homoprotocatechuic acid, m- and o-hydroxyphenylacetic acid to homogentisic acid, and anthranilic acid to 5-hydroxyanthranilic acid.

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Key concepts: Gentisic acid, Homogentisic acid, Protocatechuic acid, Benzoic acid, Phenylacetic acid, Chemistry, Salicylic acid, Hydroxybenzoic acid