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2015•Unpublished venueOpen access

Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives

Xin Qu, Hong‐Ye Zhao, Dan Wu, Lianbo Zhao, Kui Lu, Yuou Teng

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Abstract

Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields.Their structures were characterized by 1 HNMR.Three target compounds (4a~4c) have not been reported before.The results showed that: pre-treated of PC-12 cells with, cell survival rate was higher than that of quercetin.In this project, the oxidative damage model of PC-12 cells was established and the antioxidant activities of three newly synthesized quercetin derivatives were evaluated.Among them, compound 4b (30μM) showed the highest antioxidant activity against H 2 O 2 .Cell viability in pre-treated with or without compound 4b (30μM) were 53.05% and 10.31%, higher than that of quercetin (47.22%).

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Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields.Their structures were characterized by 1 HNMR.Three target compounds (4a~4c) have not been reported before.The results showed that: pre-treated of PC-12 cells with, cell survival rate was higher than that of quercetin.In this project, the oxidative damage model of PC-12 cells was established and the antioxidant activities of three newly synthesized quercetin derivatives were evaluated.Among them, compound 4b (30μM) showed the highest antioxidant activity against H 2 O 2 .Cell viability in pre-treated with or without compound 4b (30μM) were 53.05% and 10.31%, higher than that of quercetin (47.22%).

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Available abstract

Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields.Their structures were characterized by 1 HNMR.Three target compounds (4a~4c) have not been reported before.The results showed that: pre-treated of PC-12 cells with, cell survival rate was higher than that of quercetin.In this project, the oxidative damage model of PC-12 cells was established and the antioxidant activities of three newly synthesized quercetin derivatives were evaluated.Among them, compound 4b (30μM) showed the highest antioxidant activity against H 2 O 2 .Cell viability in pre-treated with or without compound 4b (30μM) were 53.05% and 10.31%, higher than that of quercetin (47.22%).

Key concepts: Quercetin, Antioxidant, Chemistry, Computer science, Combinatorial chemistry, Biochemical engineering, Biochemistry, Engineering

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