2015•Human Vaccines & ImmunotherapeuticsOpen access

Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages

Petra Kramberger, Lidija Urbas, Aleš Štrancar

Abstract

Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream monitoring. This review gives an overview on the nanoplex downstream challenges and chromatography based analytical methods for efficient monitoring of the nanoplex production.

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Key concepts: Downstream (manufacturing), Downstream processing, Upstream and downstream (DNA), Upstream (networking), Genetic enhancement, Production (economics), Computational biology, Biology