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Spontaneous remission of cyclic neutropenia during pregnancy. A case report.

Toshikazu Kimura, Ko Takakura, Takatoshi Nakagawa, Yayoi Yamamoto, Nobuyuki Kita, Yukinao Noda

Abstract

BACKGROUND: Cyclic neutropenia is characterized by regularly recurring episodes of neutropenia. It has been reported that pregnancy often has a mitigating effect on the symptoms. However, there have been no detailed studies on changes in the neutrophil count before, during and after pregnancy. CASE: A 24-year-old woman with cyclic neutropenia had a successful pregnancy, during which her symptoms improved spontaneously, with decreased severity. The disease recurred soon after pregnancy, and cyclic neutropenia was inherited by the child. CONCLUSION: Cyclic neutropenia may follow a favorable course during pregnancy, with decreased severity, but postpartum maternal and neonatal complications can occur.

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Available abstract

Key concepts: Medicine, Neutropenia, Cyclic neutropenia, Pregnancy, Congenital Neutropenia, Spontaneous remission, Pediatrics, Obstetrics