2005•Breast Cancer ResearchOpen access

Letrozole efficacy is related to human aromatase CYP19 single nucleotide polymorphisms (SNPs) in metastatic breast cancer

Rámón Colomer, Mariano Monzó, Ignasi Tusquets, Juli Rifà, José Manuel Baena, Agustí Barnadas, Lourdes Calvo, F. Carabantes, María Carmen Crespo, Montserrat Muñoz-Mateu, Antonio Llombart‐Cussac, Arrate Plazaola, Emilio Alba, Dolors Fuster, Montserrat Gilabert, B. Lloveras

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Abstract

The efficacy of aromatase inhibitors varies widely among postmenopausal breast cancer patients, but it is not associated with aromatase gene expression. We evaluated whether polymorphisms of the aromatase gene CYP19 are related to the efficacy of the aromatase inhibitor letrozole.

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Key concepts: Aromatase, Letrozole, Breast cancer, Aromatase inhibitor, Single-nucleotide polymorphism, Medicine, Internal medicine, Oncology