Preparation of liposomal in curcumin using ethanol injection method

[Objective]The present experiment was conducted to enhance the bioavailability and stability of curcumin in order to improve its clinical application.[Method]Lipsomal in curcumin was prepared by using ethanol injection method.The liposome encapsulation rate was used to screen the best processing using single factor orthogonal design.The shape characteristics and particle size of lipsomal in curcumin were investigated.[Result]The best optimization technology for preparation of lipsomal in curcumin was as follows:1.0 mg of curcumin,1∶3 ratio of lecithin to cholesterol and 20.0 mL phosphate buffer salt solution(pH 6.5) .With this method,the encapsulation rate of curcumin liposome was recorded as 72.32% and the particle size was about 830 nm.[Conclusion]The developed method for preparation of liposomal in curcumin using ethanol injection was simple and easy to contro1.The encapsulation rate and stability were very high.