The expression and significance of S100 and S100A4 in non-small cell lung cancer.

Objective To determine the expression of S100 and S100A4 in non-small cell lung cancer (NSCLC) specimens and try to find out the possible roles of S100 and S100A4 in the invasion and metastasis of NSCLC. Methods Immunohistochemical ENVISION method was used to detect the expression of S100 and S100A4 in 33 normal lung tissues near the NSCLC and 91 NSCLC tissues. Results The expression levels of S100 and S100A4 in the NSCLC tissues were significantly higher than those of the control groups (P0.05).The expression of S100 and S100A4 were not related to age (P0.05). The expression rate of S-100 was correlated to the tumor volume (P0.05), but the expression of S100A4 were not related to tumor volume (P0.05). The positive rate of S100 and S100A4 in Ⅲ stage squamous carcinoma patients were remarkably higher thanⅠstage patients (P0.05), and in Ⅲ stage adenocarcinoma patients the positive rate of S100 were higher thanⅠstage patients(P0.05).The positive rate of S100 were significantly higher in NSCLC patients with lymph node metastasis than those without lymphatic metastasis (P0.05). In squamous carcinoma patients with lymph node metastasis the positive rate of S100A4 were significantly higher than those without lymphatic metastasis(P0.05). In the squamous carcinoma patients survival for under 1 year had much higher S100 expression rate than those survival for above 1 year (P0.05).Conclusion S100 and S100A4 may play important roles in NSCLC invasion and metastasis, their expression may act as a reference to evaluate metastasis and prognosis of NSCLC.