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Stannous glucoheptonate: An effective tinning agent for Tc-99m labeling of blood cells

Rita F. Straub, G.E. Meinken, S.C. Srivastava

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Abstract

Of the various tin compounds studied, stannous glucoheptonate proved to be the most effective tinning agent for labelling blood cells with technetium 99. Much less tin was needed to achieve a rapid and satisfactory intracellular Sn(II) content. Less Sn(II) remained extracellular, facilitating its removal by oxidation or washing. Highest /sup 99m/Tc-labeling efficiencies are obtained for RBC, leukocytes, and platelets. Label stability in vitro was higher (2 to 3% washout from /sup 99m/Tc-RBC, and approx. 10% from /sup 99m/Tc-leukocytes and platelets, upon prolonged incubation with saline or plasma). The order of effectiveness for the tinning agents tested is glucoheptonate > citrate >> DTPA > PYP. 4 refs., 6 figs.

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What this paper is about

Of the various tin compounds studied, stannous glucoheptonate proved to be the most effective tinning agent for labelling blood cells with technetium 99. Much less tin was needed to achieve a rapid and satisfactory intracellular Sn(II) content. Less Sn(II) remained extracellular, facilitating its removal by oxidation or washing. Highest /sup 99m/Tc-labeling efficiencies are obtained for RBC, leukocytes, and platelets. Label stability in vitro was higher (2 to 3% washout from /sup 99m/Tc-RBC, and approx. 10% from /sup 99m/Tc-leukocytes and platelets, upon prolonged incubation with saline or plasma). The order of effectiveness for the tinning agents tested is glucoheptonate > citrate >> DTPA > PYP. 4 refs., 6 figs.

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Available abstract

Of the various tin compounds studied, stannous glucoheptonate proved to be the most effective tinning agent for labelling blood cells with technetium 99. Much less tin was needed to achieve a rapid and satisfactory intracellular Sn(II) content. Less Sn(II) remained extracellular, facilitating its removal by oxidation or washing. Highest /sup 99m/Tc-labeling efficiencies are obtained for RBC, leukocytes, and platelets. Label stability in vitro was higher (2 to 3% washout from /sup 99m/Tc-RBC, and approx. 10% from /sup 99m/Tc-leukocytes and platelets, upon prolonged incubation with saline or plasma). The order of effectiveness for the tinning agents tested is glucoheptonate > citrate >> DTPA > PYP. 4 refs., 6 figs.

Key concepts: Chemistry, Platelet, Tin, Nuclear chemistry, Reducing agent, Intracellular, Extracellular, Radiochemistry

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Stannous glucoheptonate: An effective tinning agent for Tc-99m labeling of blood cells — Research Paper | ScholarLens