2012•LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)Open access
The impact of chronic stress on behavior in rats with ligature-induced periodontal disease
Porto, Alessandra Nogueira, Alex Semenoff Segundo, Álvaro Henrique Borges, Fábio Luís Miranda Pedro, Matos, Fernanda Zamol, Tereza Aparecida Dele Vedove Semenoff
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Abstract
Purpose: To evaluate the impact of chronic stress on behavior at different time points (7, 15 and 30 days) in rats with ligature-induced periodontal disease. Methods: We selected 60 rats that were randomly divided into 2 groups: a stress group subjected to chronic stress by physical restraint one day after periodontitis induction (GE) and a control group (CG). After periods 10 animals from the GE group and 10 from the CG were analyzed in the open field and elevated plus-maze models.Results: The results show that at 7 days, increased walk in the central segment of the apparatus and peripheral open field (P<0.05) were observed in the GE group as well as increased instances of standing on two legs and self-cleaning (P<0.05). In the elevated plus-maze, no statistical differences were observed (P<0.05). At the 15-day time point, increased instances of standing on two legs and self-cleaning (P<0.05) were observed in the GE group. At 30 days, no behavioral differences were observed between the groups (P<0.05). Conclusion: We conclude that stress affect the behavior of animals subjected to 7 and 15 days of chronic stress after the induction of periodontal disease by ligation.