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Soluble intercellular adhesion molecule-1 (sICAM-1): an overview.

Anna Maria Witkowska, Maria H. Borawska

Abstract

Soluble intercellular adhesion molecule-1 (sICAM-1) represents a circulating form of ICAM-1 that is constitutively expressed or is inducible on the cell surface of different cell lines. It serves as a counter-receptor for the lymphocyte function-associated antigen (LFA-1). Interaction between ICAM-1, present on endothelial cells, and LFA-1 facilitates leukocyte adhesion and migration across the endothelium. ICAM-1 and its circulating form have been implicated in the development of any number of diseases.

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Key concepts: Intercellular Adhesion Molecule-1, Intercellular adhesion molecule, Cell adhesion molecule, Cell biology, Adhesion, Intracellular, ICAM-1, Cell adhesion