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[Comparative study of valproic acid and sodium valproate (author's transl)].

L Sorel, M Rucquoy-Ponsar, C Willems, E. Diepart, J. Harmant

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Abstract

The action of valproic acid prescribed instead of sodium valproate in strictly identical conditions was analysed in 11 epileptic children and 24 adults. No change in therapeutic effect was observed in a large proportion of cases. However, blood tests showed an increase in serum levels in most cases. Thus, valproic acid can be of help in cases hitherto treated with sodium valproate, on the same basis as diphenylhydantoin; the acid form sometimes offers an advantage over the use of the sodium salt.

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What this paper is about

The action of valproic acid prescribed instead of sodium valproate in strictly identical conditions was analysed in 11 epileptic children and 24 adults. No change in therapeutic effect was observed in a large proportion of cases. However, blood tests showed an increase in serum levels in most cases. Thus, valproic acid can be of help in cases hitherto treated with sodium valproate, on the same basis as diphenylhydantoin; the acid form sometimes offers an advantage over the use of the sodium salt.

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Available abstract

The action of valproic acid prescribed instead of sodium valproate in strictly identical conditions was analysed in 11 epileptic children and 24 adults. No change in therapeutic effect was observed in a large proportion of cases. However, blood tests showed an increase in serum levels in most cases. Thus, valproic acid can be of help in cases hitherto treated with sodium valproate, on the same basis as diphenylhydantoin; the acid form sometimes offers an advantage over the use of the sodium salt.

Key concepts: Valproic Acid, Sodium, Medicine, Sodium salt, Epilepsy, Neurology, Pharmacology, Anticonvulsant

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