2010•International Journal of PhytomedicineRequires access

Tumor inhibition and Cytotoxicity assay by aqueous extract of onion (Allium cepa) & Garlic (Allium sativum): an in-vitro analysis

Shilpa Shrivastava, Narayanan Ganesh

Abstract

The present study was aimed to investigate the effects of aqueous extract of four different varieties of Allium cepa (Onion) & Allium sativum (Garlic) on B16F10 Melanoma cell population by ex-vivo. For cytotoxicity assay, cellular micronucleus, apoptotic assay and cell viability assay were followed. Our results showed significant activity of garlic and onion as cytoprotective agents of normal cells and cytotoxicity agents for tumor cells. A significant decrease in Melanoma B16F10 cell population by crude extract was observed. Therefore, Allium cepa & Allium sativum might be a candidate for naturally healing the tumor. Keywords: Allium cepa; Allium sativum; B16F10 Melanoma; cell lines; in- vitro culture

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Key concepts: Allium, Allium sativum, Cytotoxicity, Micronucleus, Biology, Traditional medicine, Micronucleus test, In vitro