1989•Journal of VirologyOpen access

Formation of infectious hybrid virions with gibbon ape leukemia virus and human T-cell leukemia virus retroviral envelope glycoproteins and the gag and pol proteins of Moloney murine leukemia virus

Carolyn A. Wilson, M S Reitz, Hiroto Okayama, Munchen Eiden

Abstract

The gibbon ape leukemia virus, SEATO strain, and human T-cell leukemia virus type I envelope glycoproteins can be functionally assembled with a Moloney murine leukemia virus core into infectious particles. The envelope-host cell receptor interaction is the major determinant of the host cell specificity for these hybrid virions.

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Key concepts: Biology, Virology, Murine leukemia virus, Glycoprotein, Leukemia, Virus, Viral envelope, Gammaretrovirus