2002•Korean Journal of Veterinary ServiceRequires access

Effect of picolinic acid on nitric oxide synthesis in murine macrophage

Oh-Deog Kwon, Jae-Cheul Do, Keun‐Woo Lee

Abstract

To determine the effect of picolinic acid on NOㆍ production, murine macrophages were incubated with either medium, various concentrations of picolinic acid, or IFN- plus picolinic acid for 48 hr. Picolinic acid does not induce NOㆍ production by itself, it acted synergistically with INF- for the induction of reactive nitrogen intermediate production in murine macrophages. Thymidine incorporation appeared to be reciprocally related to nitrite levels, suggesting that IFN- plus picolinic acid induced NOㆍ synthesis exerted antiproliferative effects.

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Key concepts: Picolinic acid, Nitric oxide, Chemistry, Macrophage, Nitric acid, Biochemistry, Nitrite, In vitro