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Monoamine oxidase inhibitors potentiate phenylethylamine effects in rhesus monkeys.

Staub Ra, Gillin Jc, Robert Wyatt

Abstract

Acute pretreatment with either a Type A monoamine oxidase inhibitor (MAOI), clorgyline, or a Type B MAOI, pargyline, markedly reduced the dose of phenylethylamine (PEA) required to produce checking and a variety of other behavioral changes in rhesus monkeys. Doses of PEA (5 or 10 mg/kg) which previously were without effect, now produced significant behavioral changes in pretreatment animals.

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Key concepts: Clorgyline, Pargyline, Monoamine oxidase, Monoamine oxidase inhibitor, Pharmacology, Monoamine oxidase B, Tranylcypromine, Monoamine oxidase A