Change of matrix metallo proteinase-9, interleukin-6, tumor necrosis factor-a dynamic and its relationship with peripheral edema after cerebral hemorrhage.

Objective To study the changes of serum matrix metalloproteinase-9(MMP-9),IL-6,TNF-α at different times and its relation with lesion edema in the cerebral hemorrhage patients.Methods Serum MMP-9,IL-6,TNF-α levels in 80 cases of cerebral hemorrhage patients(observation group) 24 h,72 h,7 d and 14 d after cerebral hemorrhage were measured by radioimmunity methods,and their respective focal edema volumes at the corresponding time were detected,and compared with 50 cases with normal physical examination(control group).Results Hydrocephalus of patients in observation group peaked at 72 h,followed by a slow decline.Serum MMP-9,IL-6 levels within 24 h were significantly increased,reached the peak at 72 h after morbidity,accorded with the peak of cerebral edema,decreased significantly after 7 d,closed to normal levels at 14 d,and were significantly higher than that of control group(P0.01).TNF-α reached to the peak level 24 h after morbidity and then gradually declined,were significantly higher at 24 h、 72 h than that of the control group(P0.01).MMP-9 was positively correlation with IL-6,TNF-α,hematoma volume,edema volume,edema ratio,the degree of deterioration of the conditions at 24 h and 72 h(P0.01).Conclusions Serum MMP-9,cytokines(IL-6,TNF-α) are over-expressed and have the dynamic changes over time after cerebral hemorrhage,MMP-9 is correlated with the edema volume and deteriorated condition and has more stronger correlation with relative size of edema.MMP-9,IL-6,TNF-α involve in the formation of edema and influence each other.