2009•PubMedOpen access

Reversal by sugammadex.

Pramila Bajaj

Abstract

Reversal agents are often used to ensure the reversal of nondepolarizing neuromuscular blockade (NMB). The most widely used are the acetylcholinesterase inhibitors, neostigmine, and edrophonium. However, these agents are only partially effective against profound NMB, especially in the presence of volatile anaesthetics such as sevoflurane, and may also be associated with adverse effects, such as cholinergic cardiovascular and gastrointestinal events.1

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Available abstract

Key concepts: Sugammadex, Medicine, Neostigmine, Edrophonium, Neuromuscular Blockade, Sevoflurane, Anesthesia, Acetylcholinesterase