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Thienopyridine Response Variability and Resistance

Udaya S. Tantry, Thomas Suarez, Paul Alfred Gurbel

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Abstract

This chapter contains sections titled: Introduction Mechanism of action Clopidogrel resistance - definition Laboratory evaluation of clopidogrel responsiveness Effect of time of treatment and dose on platelet responsiveness to clopidogrel Mechanism of clopidogrel resistance Relation of clopidogrel non-responsiveness and high post-treatment platelet reactivity to adverse clinical events Management of clopidogrel resistance New P2Y12 receptor antagonists Conclusion References

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What this paper is about

This chapter contains sections titled: Introduction Mechanism of action Clopidogrel resistance - definition Laboratory evaluation of clopidogrel responsiveness Effect of time of treatment and dose on platelet responsiveness to clopidogrel Mechanism of clopidogrel resistance Relation of clopidogrel non-responsiveness and high post-treatment platelet reactivity to adverse clinical events Management of clopidogrel resistance New P2Y12 receptor antagonists Conclusion References

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Available abstract

This chapter contains sections titled: Introduction Mechanism of action Clopidogrel resistance - definition Laboratory evaluation of clopidogrel responsiveness Effect of time of treatment and dose on platelet responsiveness to clopidogrel Mechanism of clopidogrel resistance Relation of clopidogrel non-responsiveness and high post-treatment platelet reactivity to adverse clinical events Management of clopidogrel resistance New P2Y12 receptor antagonists Conclusion References

Key concepts: Clopidogrel, Thienopyridine, P2Y12, Medicine, Platelet, Internal medicine, Pharmacology, Cardiology

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