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Techniques in Preparative Chiral Separations

Pilar Franco, Cristina Minguillón

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Abstract

Introduction Crystallization techniques Chromatographic techniques Liquid chromatography High pressure liquid chromatography / medium pressure liquid chromatography (HPLC/MPLC) Flash chromatography Simulated moving bed (SMB) Closed-loop recycling with periodic intra-profile injection (CLRPIPI) Countercurrent chromatography (CCC/CPC) Subcritical and supercritical fluid chromatography Gas chromatography Enantioselective membranes Other methods Chiral extractions Preparative gel electrophoresis and thin-layer chromatography Enantioselective distillations and foam flotation Global considerations

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Introduction Crystallization techniques Chromatographic techniques Liquid chromatography High pressure liquid chromatography / medium pressure liquid chromatography (HPLC/MPLC) Flash chromatography Simulated moving bed (SMB) Closed-loop recycling with periodic intra-profile injection (CLRPIPI) Countercurrent chromatography (CCC/CPC) Subcritical and supercritical fluid chromatography Gas chromatography Enantioselective membranes Other methods Chiral extractions Preparative gel electrophoresis and thin-layer chromatography Enantioselective distillations and foam flotation Global considerations

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Available abstract

Introduction Crystallization techniques Chromatographic techniques Liquid chromatography High pressure liquid chromatography / medium pressure liquid chromatography (HPLC/MPLC) Flash chromatography Simulated moving bed (SMB) Closed-loop recycling with periodic intra-profile injection (CLRPIPI) Countercurrent chromatography (CCC/CPC) Subcritical and supercritical fluid chromatography Gas chromatography Enantioselective membranes Other methods Chiral extractions Preparative gel electrophoresis and thin-layer chromatography Enantioselective distillations and foam flotation Global considerations

Key concepts: Chromatography, Supercritical fluid chromatography, Countercurrent chromatography, Chemistry, High-performance liquid chromatography, Gas chromatography, Aqueous normal-phase chromatography, Chromatography column

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