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1982•Advances in Alcohol & Substance AbuseRequires access

Opiate Receptors and Endorphins:

Eric Simon

Open publisher page 6 citations

Abstract

This review presents a chronological discussion of the discovery of opiate receptors and the endogenous opioid peptides. After a summary of the properties and distribution of the receptors and their endogenous ligands, the possible function of the endogenous opioid system is discussed. Evidence for a role of this system in endogenous pain modulation and in opiate addiction is presented. The nature of the evidence and the absence of definitive proof of a causal involvement of the opiate receptor-endorphin system are emphasized.

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What this paper is about

This review presents a chronological discussion of the discovery of opiate receptors and the endogenous opioid peptides. After a summary of the properties and distribution of the receptors and their endogenous ligands, the possible function of the endogenous opioid system is discussed. Evidence for a role of this system in endogenous pain modulation and in opiate addiction is presented. The nature of the evidence and the absence of definitive proof of a causal involvement of the opiate receptor-endorphin system are emphasized.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This review presents a chronological discussion of the discovery of opiate receptors and the endogenous opioid peptides. After a summary of the properties and distribution of the receptors and their endogenous ligands, the possible function of the endogenous opioid system is discussed. Evidence for a role of this system in endogenous pain modulation and in opiate addiction is presented. The nature of the evidence and the absence of definitive proof of a causal involvement of the opiate receptor-endorphin system are emphasized.

Key concepts: Opiate receptors, Endorphins, Endogeny, Opiate, Endogenous opioid, Receptor, Opioid, Opioid peptide

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