2012•Clinical & Experimental ImmunologyOpen access

Cellular immune responses in multiple sclerosis patients treated with interferon-beta

Marta F. Bustamante, Jordi Río, Z Castro, Álex Sánchez‐Pla, Xavier Montalbán, Manuel Comabella

Abstract

We investigated cellular immune responses at baseline in peripheral blood mononuclear cells (PBMC) of patients with multiple sclerosis (MS) treated with interferon (IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin (IL)-17A, IL-17F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders.

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Key concepts: Peripheral blood mononuclear cell, Multiple sclerosis, Immune system, Immunology, Cytokine, Medicine, Interferon, Interferon gamma