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1995•Thrombosis and HaemostasisRequires access

Resistance to Activated Protein C and Factor V Leiden as Risk Factors for Venous Thrombosis

Rogier M. Bertina, Pieter H. Reitsma, Frits R. Rosendaal, Jan P. Vandenbroucke

Open publisher page 159 citations

Abstract

The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.

About this research paper

What this paper is about

The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.

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OpenAlex reports 159 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.

Key concepts: Factor V Leiden, Venous thrombosis, Thrombosis, Thrombophilia, Medicine, Risk factor, Protein C, Activated protein C resistance

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