1997•Comprehensive physiologyRequires access

Of Membrane Stability and Mosaics: The Spectrin Cytoskeleton

Jon S. Morrow, David L. Rimm, Scott P. Kennedy, Carol D. Cianci, John H. Sinard, Scott A. Weed

Abstract

Abstract The sections in this article are: The Red Cell Membrane Skeleton How Does the Spectrin Membrane Skeleton Stabilize the Red Cell? The Trilayer Couple—Spectrin as A Membrane Organizer Components of the Erythrocyte Membrane Skeleton Spectrin Actin Ankyrin Protein 4.1 Adducin Dematin (Protein 4.9) Pallidin (Protein 4.2) p55 (an Erythrocyte Membrane‐Associated Guanylate Kinase) Stomatin Tropomyosin and Tropomodulin Dynamin Interactions with Phospholipids The Spectrin Skeleton of Non‐Erythroid Cells Spatial and Temporal Polarization Proteins Interacting with Spectrin in Non‐Erythroid Cells Cytoskeletal Elements Adhesion Proteins Evolving Concepts Conclusions: The Linked Mosaic Model

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Available abstract

Key concepts: Spectrin, Ankyrin, EPB41, Cytoskeleton, Band 3, Cell biology, Actin, Red blood cell