2009•Current Protocols in PharmacologyRequires access

Monocrotaline‐Induced Pulmonary Hypertension in Wistar Rats

Markus Rey, Patrick Hess, Martine Clozel

Abstract

Abstract Pulmonary arterial hypertension (PAH) is a debilitating and often fatal disease characterized by a progressive increase in pulmonary vascular resistance that leads to right ventricular failure. Described in this unit is an in vivo model of monocrotaline‐induced pulmonary hypertension in rats that can be used to assess the effects of antihypertensive agents on pulmonary artery pressure and right ventricular hypertrophy. Curr. Protoc. Pharmacol. 46:5.56.1‐5.56.11. © 2009 by John Wiley & Sons, Inc.

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Key concepts: Pulmonary hypertension, Cardiology, Internal medicine, Pharmacology, Medicine, Chemistry