1984•FEBS LettersRequires access

Homologies between a brain‐specific identifier (ID) sequence and regions of Harvey murine sarcoma virus and Rous sarcoma virus genomes

János Minárovits, Zoltán Kovács, I Földeş

Abstract

As a step toward understanding of the tissue specificity of cellular transformation by RNA tumor viruses were looked for the presence of a putative brain specific regulatory (identifier) sequence (C82B) in the genome of various oncornaviruses. The genomes of Harvey murine sarcoma virus and Rous sarcoma virus contain sequences flanking the viral oncogenes with greater than 80% and greater than 60% homology to C82B, respectively. We suggest that identifier sequences acquired by oncoviruses may determine the potential target cells of malignant transformation after virus penetration.

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Key concepts: Rous sarcoma virus, Biology, Genome, Virology, Virus, Viral transformation, Oncovirus, Sarcoma