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Different inhibitory effect of nitrogen mustard (HN2) and TS-160 (HN3) on choline transport in L 5178Y lymphoblasts.

Ujházy, Jordan Kolarov, S Kuźela, Krempaský, E Bohunická

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Abstract

The inhibitory effect of the alkylating agents nitrogen mustard (HN2) and TS-160 (HN3) on the choline transport in L 5178Y lymphoblasts was studied. The two alkylating agents differed in the degree and in the nature of the inhibition of the process examined. Competitive inhibition of choline transport by HN2 was confirmed, whereas the noncompetitive inhibition by the less efficient inhibitor HN3 has been found. The results achieved indicate that in spite of the structural similarity between HN2 and HN3 only the former is transported into L 5178Y lymphoblasts by the choline transport carrier.

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What this paper is about

The inhibitory effect of the alkylating agents nitrogen mustard (HN2) and TS-160 (HN3) on the choline transport in L 5178Y lymphoblasts was studied. The two alkylating agents differed in the degree and in the nature of the inhibition of the process examined. Competitive inhibition of choline transport by HN2 was confirmed, whereas the noncompetitive inhibition by the less efficient inhibitor HN3 has been found. The results achieved indicate that in spite of the structural similarity between HN2 and HN3 only the former is transported into L 5178Y lymphoblasts by the choline transport carrier.

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Available abstract

The inhibitory effect of the alkylating agents nitrogen mustard (HN2) and TS-160 (HN3) on the choline transport in L 5178Y lymphoblasts was studied. The two alkylating agents differed in the degree and in the nature of the inhibition of the process examined. Competitive inhibition of choline transport by HN2 was confirmed, whereas the noncompetitive inhibition by the less efficient inhibitor HN3 has been found. The results achieved indicate that in spite of the structural similarity between HN2 and HN3 only the former is transported into L 5178Y lymphoblasts by the choline transport carrier.

Key concepts: Choline, Nitrogen mustard, Lymphoblast, Chemistry, Non-competitive inhibition, Inhibitory postsynaptic potential, Biochemistry, Enzyme

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Different inhibitory effect of nitrogen mustard (HN2) and TS-160 (HN3) on choline transport in L 5178Y lymphoblasts. — Research Paper | ScholarLens