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2013•Critical CareOpen access

Influence of temperature on the cardiac action of dobutamine and levosimendan in isolated perfused hearts

U Aldenhoff, R Vicenzi-Moser, Martin N. Vicenzi, David Benjamin Konrad, E Schwarzl, Wolfgang G Toller

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Abstract

Inotropic agents (catecholamines or calcium-sensitizers) are frequently used in hypothermic as well as hyperthermic patient conditions. Divergent results from animal experiments raise doubt as to whether they act to the same extent at different body temperatures. Thus, we studied the influence of clinically relevant temperatures on the hemodynamic effects of dobutamine and levosimendan using the Langendorff model of isolated perfused hearts.

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Inotropic agents (catecholamines or calcium-sensitizers) are frequently used in hypothermic as well as hyperthermic patient conditions. Divergent results from animal experiments raise doubt as to whether they act to the same extent at different body temperatures. Thus, we studied the influence of clinically relevant temperatures on the hemodynamic effects of dobutamine and levosimendan using the Langendorff model of isolated perfused hearts.

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Available abstract

Inotropic agents (catecholamines or calcium-sensitizers) are frequently used in hypothermic as well as hyperthermic patient conditions. Divergent results from animal experiments raise doubt as to whether they act to the same extent at different body temperatures. Thus, we studied the influence of clinically relevant temperatures on the hemodynamic effects of dobutamine and levosimendan using the Langendorff model of isolated perfused hearts.

Key concepts: Levosimendan, Dobutamine, Inotrope, Medicine, Cardiology, Hemodynamics, Internal medicine, Intensive care medicine

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Influence of temperature on the cardiac action of dobutamine and levosimendan in isolated perfused hearts — Research Paper | ScholarLens