Giucocorticoid-Insensitive Bronchial Asthma

This chapter contains section titled: Introduction Molecular Mechanisms of Glucocorticoid Action Transcriptional Interference by the Glucocorticoid Receptor Glucocorticoids Interfere with Ap-1 Activity Inhibition of NF-KB Activation by Glucocorticoids Glucocorticoid-Induced I-KBa Synthesis Inhibits NF-KB Activity Primary Glucocorticoid Resistance Glucocorticoid Insensitivity in Asthma Glucocorticoid Bioavailability in Glucocorticoidinsensitive Asthma Cellular Immune Responses in Glucocorticoidinsensitive Asthma Induction of Glucocorticoid Insensitivity in Vitro Binding of Glucocorticoid Receptor to Glucocorticoid-Response Elements on DNA Increased Expression of GCRP in Glucocorticoidinsensitive Asthma Allergen Exposure and Glucocorticoid-Receptor Binding Affinity Glucocorticoid Resistance in Other Tissues in Glucocorticoid-Insensitive Asthma Hypothalamic-Pituitary-Adrenal Axis in Glucocorticoid-Insensitive Asthma Bone Metabolism in Glucocorticoid-Insensitive Asthma Conclusions References